14 RESULTS
COMMENT This is an interesting paper. Of additional relevance is the role of aluminum, usually neglected, in the obstruction of tau degradation. Walton recently demonstrated in a rat model that aluminum inhibited activity of PP2A. PP2A is the major phosphate-remo
COMMENT Walton's recent study of pyramidal neurons from the hippocampus of autopsy-confirmed AD patients found that all NFTs were associated with cytoplasmic aluminum. While the absorption of the metal by the NFTs may reduce inflammation and oxidation, NFT d
COMMENT This paper seems to skirt many years of autopsy studies finding that the senile plaques have marginal statistical capacity to distinguish normal from AD patients, such as Davis et al., 1999. Also in 1999, Lue et al. concluded that soluble Aβ posed the gre
COMMENT A practical problem with transgenic animals is that most focus on single aspects of the biology of AD such as amyloid. This paper broadens the scope of inquiry to a second variable, in this case, nitric oxide. It is of interest that aluminum, which epidem
COMMENT The research community appears to play with half a deck of cards by ignoring the role of metals, particularly aluminum in co-causation of Alzheimer dementia. Ghribi et al., in a series of studies, investigated the effect of aluminum on the endoplasmic ret
COMMENT This paper is a solid confirmation of many previous human autopsy studies that showed there is little correlation between the visible AD lesions and rates of dementia. The feedback relationships among amyloid and NFT pathology and toxic metals in dementia
COMMENT These studies confirm the confusion that developed over the years that AD and AD with dementia are the same issue. Progression to AD with dementia is a separate issue from Braak stage. A growing number of autopsy studies confirm the findings of the Nun St
COMMENT be significantly preventable in the U.S. (1). Colin Meyer's comment that silicic acid, present
COMMENT A number of studies demonstrate that iron and aluminum are co-deposited in the brains of Alzheimer patients (1) and that the metals interact in enhancement of oxidation. Walton has developed a method of staining aluminum in hippocampal neurons in humans w
COMMENT Clioquinol is a 8-hydroxyquinoline derivative and will bond with aluminum, another risk factor for Alzheimer's. Del Castilo et al., in their study of chromatin staining methods, reported that the "most suitable compounds for forming fluorescent
COMMENT Grosche from the Nun Study demonstrated with autopsy that brain cell death: i.e. brain atrophy, is what produces the dementia of AD rather than the density of plaque and tangle deposits. Heme deficiency has been identified as one cause of brain cell death
COMMENT One effective way to enhance adequate functioning of the α-secretase, which is zinc-based, may be to maintain normal zinc serum levels. Tully from the Nun Study found that normal fasting serum zinc, measured one year before death, showed moderate to stron
COMMENT Aluminum could be a co-factor in the findings of Stokin and collegues. Aluminum was found to inhibit neurofilament assembly, cytoskeletal incorporation, and axonal transport by Shea et al, 1997. Deloncle et al, 2001 found that aluminum L-glutamate causes
COMMENT Curcumin also impacts aluminum binding to chromatin DNA, which is of relevance. After aluminum mordanting of chicken blood smears, several chelating dyes and reagents were found to detect metal binding to chromatin DNA by fluorescence microscopy. One of t
